design of water-soluble, amine and imine
macrocyclic ligands is a bioinorganic approach
to synthesize simple inorganic analogues
to the active site P-460 of Hydroxylamine
Oxidoreductase (HAO). This enzyme HAO catalyzes
the four-electron oxidative conversion of
hydroxylamine to nitrite in the biological
nitrogen cycle. The exploration of the complexes'
reactivity towards substrates such as NH2OH,
N2H4, N2O, and NO is envisioned. The ultimate
goal of this research is to broaden our
understanding of the interplay of the active
site, covalently bound and potentially redox-active
side-chains, metal-metal interactions, and
electron acceptors during the course of
the hydroxylamine oxidation.